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Monday, July 06, 2009

more question for bioenergetics and oxidative phosphorylation

1. Which one of the following statements is most correct?
A Oxidation of pyruvate to carbon dioxide and water does not involve the TCA cycle.
B The major pathway for electron transfer to oxygen in the electron transport system does not involve pyridine nucleotides.
C An adequate supply of ADP is required for maximal respiration by mitochondria.
D Coenzyme Q is a prosthetic group of a flavoprotein.
E Substrate level phosphorylation cannot occur in the absence of oxygen

2. Which one of the following enzyme systems may be used as a marker enzyme for mitochondrial electron transport system?

AGlucose 6-phosphate dehydrogenase
BSuccinate dehydrogenase (succinate-cytochrome c reductase)
CPhosphoenolpyruvate carboxykinase
DLactate dehydrogenase
EAcetyl-CoA carboxylase



3. Rotenone inhibits malate oxidation but not succinate oxidation because

Ait is a competitive inhibitor of malate dehydrogenase.
Bit does not react with flavoprotein enzymes.
Cit inhibits at the NADH dehydrogenase while succinate dehydrogenase interacts with the respiratory chain at ubiquinone, bypassing this site of inhibition.
Dit inhibits at cytochrome b while succinate dehydrogenase interacts with the respiratory chain at cytochrome c.
Eit inhibits at the cytochrome oxidase but succinate is oxidized by a flavin oxidase.


4. Cyanide is a deadly poison because it

Abinds to myoglobin.
Binterferes with respiratory control.
Cforms addition compounds with important aldehydes such as pyridoxal.
Dreacts with cytochrome oxidase.
Einhibits the cytochrome P-450 monooxygenases.


5. The main function of the mitochondrial electron transport chain is to

Agenerate a P/O ratio of 2.5.
Brecycle NAD for glycolysis.
Cprovide reducing equivalents.
Dlower the oxidation state of the cell.
Egenerate energy for ATP formation.


7. Which of the following tissues has the lowest respiratory rate?

Aadipose tissue
Bbrain
Cliver
Dred blood cell
Eskeletal muscle



sources: https://med-eval.med.uiuc.edu/cgi-bin/exam/practicefeedback.p


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